Lake house vacation rentals in Seneca

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Top-rated lake house rentals in Seneca

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Westminster

4.99 out of 5 average rating, 101 reviews

Dream Weaver: Lakefront• jacuzzi• dog friendly

🐾 Your Pet-Friendly Retreat Awaits at Dream Weaver Cottage! 🐾 Indulge in a relaxing getaway where every detail has been thoughtfully designed for your comfort. From spacious bedrooms featuring luxurious bedding to a fully stocked kitchen and a 75’ TV with Bluetooth sound system, our aim is to exceed your expectations.Our pet-friendly oasis also features a fire pit and a gas grill, perfect for outdoor gatherings and memorable cookouts.Discover the beauty of nearby wineries, breweries & waterfalls

Guest favorite

Home in Hartwell

4.99 out of 5 average rating, 180 reviews

The Cobb Lake House

Looking for a Lake Hartwell getaway! This spacious lakefront home has room for everyone! Spend your mornings relaxing in the screened-in porch with a cup of coffee. Afternoons can be enjoyed down by the dock where you can sunbathe, kayak or just float around. Fish, dock your boat or jet ski. Public boat ramps are just a short drive away. Relax by the outdoor fire pit or enjoy the WOOD BURNING fireplace in the living room off a spacious kitchen and dining room. A great way to spend a vacation.

Guest favorite

Home in West Union

4.94 out of 5 average rating, 144 reviews

Sunsets and Siestas -Lake Keowee home near Clemson

Sunsets and Siestas - A beautiful Lake Keowee waterfront home, near Clemson, SC. Make our lovely 3700 sq ft lake house on Lake Keowee your home away from home! Perfect for family gatherings, retreats, and more. We can comfortably sleep up to 16 people and with three separate sitting rooms, there's ample space for games and conversation. Enjoy a day on the lake boating, and swimming, relax in our hot tub or our private front yard pool, or venture out and explore beautiful upstate South Carolina.

Guest favorite

Home in Easley

4.9 out of 5 average rating, 299 reviews

“Lake House Paradise” Waterfront Oasis

STORM UPDATE: The lake suffered a broken dam and the water level is down... the dock suffered damage from the flooding and is unusable. “Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views of the water. Your Master Bathroom has a large luxury marble shower. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 186 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry! No fireworks.

Guest favorite

Home in Anderson

4.95 out of 5 average rating, 109 reviews

Clemson ,Lake Hartwell, Waterfront, pontoon rental

Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 16 featuring 7 bedrooms with 2 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.

Superhost

Home in Six Mile

4.85 out of 5 average rating, 221 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Superhost

Home in Anderson

4.85 out of 5 average rating, 189 reviews

Lake Living with Amazing Views of Lake Hartwell

Stunning lake views in highly popular The Shoals in Portman Marina located on Lake Hartwell. Bring your pets with you, we are pet-friendly, and they'll love running around the fenced in backyard. Very large back deck overlooking the lake while you have morning coffee, grill or just relax! We also are located in a very nice, quiet neighborhood in cul de sac. Short drive to Clemson University for games or student/family events. Also, short drive to downtown Anderson and Anderson University.

Guest favorite

Home in Seneca

4.94 out of 5 average rating, 109 reviews

Getaway on Lake Hartwell: Pontoon Rental, Clemson

Our three bedroom house is located on lake Hartwell and just a 10 minute drive to Clemson University or 25 minutes by boat. During your stay you can enjoy access to the dock and beach which are a quick golf cart ride away. We have two kayaks and four paddle boards available for your use. Off the back of the detached garage there is a furnished screened in deck with grill that overlooks the end of the cove and fire pit below. We have coolers, bagged ice, fishing poles etc upon request.

Guest favorite

Home in Hartwell

4.93 out of 5 average rating, 118 reviews

Lake house waterfront, 10 min to downtown w Kayaks

The 'Hart' of the Lake! Quaint & cozy waterfront lake house in the heart of Lake Hartwell. Quiet and tucked away street with very few cars (lots of deer), but only 10 minutes from historic downtown Hartwell. Kayaks and floats available for use. Fire pit, gas grill, and large wrap-around deck perfect for entertaining. Enjoy the sunset on our private dock. Great for a weekend retreat at the lake or an extended stay. 200 Mbps wifi, ample parking, boat rental and boat drop nearby.

Guest favorite

Home in Anderson

4.99 out of 5 average rating, 191 reviews

Lake Escape

This is the perfect lake house for your next family vacation, Clemson football game, or just a long weekend at the lake! Enjoy full access to Lake Hartwell with a private dock and swimming area. The house is located just 20 minutes from both Clemson and Anderson and also just 5 minutes from Portman Marina. Kayaks do not come included with the house but can be rented if inquired about ahead of time. Come enjoy some nature, relaxation, and fun at the Lake Escape!

Guest favorite

Home in Easley

4.91 out of 5 average rating, 145 reviews

Large lake house - 15 min to Downtown Greenville

Luxurious 5000 sq ft 3-story lake house in serene neighborhood, 15 min to downtown Greenville. Sleeps 12 in 9 beds, 4.5 baths. Enjoy pool table/bar, private dock with swim platform, inflatable toys and 2 stand up paddle boards. Stunning views, 3-car garage, lake-side fire pit, grill. Executive suite with office space, Primary suit with lake views. Perfect for relaxation, water activities, and cherished memories. Book now for an unforgettable escape!