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Vacation home rentals in Panama
Find and book unique vacation home rentals on Airbnb
Top-rated vacation home rentals in Panama
Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama vacation home rentals
Family-friendly vacation home rentals
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Vacation home in El Chirú
4.85 out of 5 average rating, 20 reviewsApartment in Buenaventura
![](https://a0.muscache.com/im/pictures/miso/Hosting-2086339/original/d0b65288-775f-4a0f-a22e-1b9ab136d9e1.jpeg?im_w=720)
Vacation home in La Pintada
4.38 out of 5 average rating, 16 reviewsLa Pintada Inn full hotel for private group
![](https://a0.muscache.com/im/pictures/aef5c48d-a16c-4a59-8990-77ba479d6a26.jpg?im_w=720)
Vacation home in Panamá
Lovely place with exclusive private pool
![](https://a0.muscache.com/im/pictures/5f16795c-f08c-467c-be9c-6ac712815d44.jpg?im_w=720)
Vacation home in Juan Gallego
4.84 out of 5 average rating, 82 reviewsPebos Reef, 12 guests, Amazing views!!
Vacation home rentals with a patio
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Vacation home in Anton Valley
4.89 out of 5 average rating, 47 reviewsAdorable 2 bedroom home near India Dormida hiking
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Vacation home in Volcán
4.83 out of 5 average rating, 35 reviewsBeautiful cabin with balcony
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Vacation home in Rio Hato
4.83 out of 5 average rating, 6 reviewsOcean view studio Town Center Playa Blanca Rio Hat
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Vacation home in Bocas del Toro
4.58 out of 5 average rating, 40 reviewsPrivate Luxury Over the Water Bungalow
![](https://a0.muscache.com/im/pictures/miso/Hosting-54201257/original/732d308f-4aa6-4e7c-bc17-1980d6ba4366.jpeg?im_w=720)
Vacation home in Maria Chiquita
5 out of 5 average rating, 23 reviewsPlaya Escondida, Caribe Depa for 8 pax
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Vacation home in San Carlos
4.88 out of 5 average rating, 32 reviewsWelcome to our house in Playa Corona
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Vacation home in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPlaya Escondida, Apt with Spectacular Ocean View
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Vacation home in Maria Chiquita
5 out of 5 average rating, 6 reviewsPlaya Escondida: condo ocean view 3 hab
Vacation home rentals with a washer and dryer
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Vacation home in Arraiján
4.8 out of 5 average rating, 50 reviewsApartamento En Club De Playa, With Pool and BBQ
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Vacation home in San Carlos
4.97 out of 5 average rating, 32 reviewsBeachfront apartment in Punta Caelo
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Vacation home in Chitré
4.95 out of 5 average rating, 37 reviewsCASA EdditA ° Acogedora casa en Chitré
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Vacation home in Maria Chiquita
4.84 out of 5 average rating, 37 reviewsPlaya Escondida apt 200 mt2, 4r 4b waterfront
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Vacation home in Panamá
4.78 out of 5 average rating, 68 reviewsBrand new apartment on Calle 50 w/Cinta Costera
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Vacation home in Bajo Boquete
4.64 out of 5 average rating, 25 reviewsRio Verde: Splendid suite w/ hammock & river view
![](https://a0.muscache.com/im/pictures/miso/Hosting-52838897/original/1c93f6f7-21e7-4817-b547-4e7d605f1439.jpeg?im_w=720)
Vacation home in Coronado
4.85 out of 5 average rating, 33 reviewsModern Beach House With Private Beach Access
![](https://a0.muscache.com/im/pictures/5a43942c-7a7b-418c-9ac1-08a2c954786f.jpg?im_w=720)
Vacation home in Los Naranjos
5 out of 5 average rating, 3 reviewsOrange Country Apartment #3
Destinations to explore
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- Family travel hub Tips and inspiration
- Family budget travel Get there for less
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- Outdoor adventure Explore nature with the family
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- Kid-friendly state parks Check out these family-friendly hikes