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Vacation rentals in Santa Cruz de la Sierra

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz de la Sierra

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Apartment in Santa Cruz de la Sierra

5.0 out of 5 average rating, 30 reviews

Santa Cruz>Bolivia>Equipetrol. Clean/Fancy/Safe

Sofisticado departamento con diseño moderno y acogedor, ideal para viaje de negocios/descanso. Protocolo limpieza anti COVID-19. Vistas increíbles a la ciudad, amplios ventanales, locación estratégica entre aeropuerto, zona de negocios/diversión y centro de la ciudad. Ubicado en Equipetrol frente a Mall Ventura, Starbucks, Torre Duo, Hotel Camino Real, Supermercado Tía y a 100 metros de Manzana 40, rodeado de las mejores tiendas de shopping, parques, restaurantes, cafeterías y bares de la zona.

Sep 19 – 26

$35 per night
Guest favorite

Loft in Santa Cruz de la Sierra

4.9 out of 5 average rating, 163 reviews

Executive loft with amazing view

This loft is perfectly designed for guests doing travel or business. Located on a quiet street near to the city zoo in a centrally-located area offers easy access to many attractions, including the corporate zone, airport, restaurants and malls. The Loft & Kitchen: • 50” LED TV • Netflix • Wifi Services • Washer Dryer • Balcony • Microwave • Pots, pans, platters • Minibar Common Spaces: • Gym • Game room • Sauna • 3 Cinema rooms • 24/7 security • Pool • Barbecue grill

May 24 – 31

$22 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

4.96 out of 5 average rating, 28 reviews

Exclusive apartment in Equipetrol

Beautiful apartment in the best area of Santa Cruz, near Manzana 40, Ventura Mall, Hipermaxi and Fidalga supermarkets, distraction areas, hotels and the best restaurants in the city. It has different recreation areas such as swimming pool, steam and dry sauna sauna, games room, beautiful views of the city. The apartment consists of a double bed and a sofa bed, two TV, washer and dryer, oven, microwave, electric stove, tableware, refrigerator and WIFI network.

Sep 14 – 21

$32 per night

Popular amenities for Santa Cruz de la Sierra vacation rentals

Stay near Santa Cruz de la Sierra's top sights

Ventura Mall131 locals recommend
Parque Urbano18 locals recommend
Fexpocruz6 locals recommend
Cine Center23 locals recommend
Las Brisas65 locals recommend
Mutualista Market8 locals recommend

Other great vacation rentals in Santa Cruz de la Sierra

Guest favorite

Apartment in Santa Cruz de la Sierra

4.89 out of 5 average rating, 19 reviews

Luxurious 2-suite apartment in Equipetrol

Nov 15 – 22

$77 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

5.0 out of 5 average rating, 26 reviews

Luxury Apartment - Stunning Pool - Sky Lumiere 1BR

Nov 17 – 24

$45 per night
Superhost

Apartment in Santa Cruz de la Sierra

4.83 out of 5 average rating, 42 reviews

Luxurious apartment in Equipetrol

Sep 2 – 9

$59 per night
Guest favorite

Condo in Santa Cruz de la Sierra

5.0 out of 5 average rating, 40 reviews

Santa Cruz is waiting for you, a lot to know and do.

Jun 17 – 24

$21 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

4.94 out of 5 average rating, 34 reviews

Luxurious apartment in front of Ventura

Jul 31 – Aug 7

$43 per night
Guest favorite

Condo in Santa Cruz de la Sierra

4.92 out of 5 average rating, 48 reviews

Centrally located apartment in Equipetrol

Jul 29 – Aug 5

$42 per night
Guest favorite

Condo in Santa Cruz de la Sierra

4.95 out of 5 average rating, 95 reviews

Comfortable and Exclusive Apartment-Excel. Location

Jul 7 – 14

$25 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

5.0 out of 5 average rating, 21 reviews

Luxurious 1 Sleeping Board in Uptown Equipetrol

Jul 25 – Aug 1

$33 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

4.85 out of 5 average rating, 34 reviews

New apartment. Perfect location

Apr 13 – 20

$20 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

4.9 out of 5 average rating, 30 reviews

Spacious, luxurious, and the best view

Nov 18 – 25

$44 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

5.0 out of 5 average rating, 27 reviews

Smart Apartment in Equipetrol a Premiere 1B

Nov 2 – 9

$31 per night
Guest favorite

Apartment in Santa Cruz de la Sierra

5.0 out of 5 average rating, 11 reviews

Exclusive Full Smart Department

Oct 13 – 20

$28 per night

Quick stats about vacation rentals in Santa Cruz de la Sierra

Total rentals

3.3K properties

Rentals with dedicated workspaces

1.8K properties have a dedicated workspace

Rentals with a pool

2.2K properties have a pool

Pet-friendly rentals

900 properties allow pets

Family-friendly rentals

990 properties are a good fit for families

Total number of reviews

37K reviews

Frequently Asked Questions

  • How is the weather in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has a tropical savanna climate. During the wet season from November to March, temperatures range from 68°F to 86°F (20°C to 30°C). In the dry season from April to October, temperatures vary between 59°F and 79°F (15°C to 26°C).

  • What are some of the best things to do in Santa Cruz de la Sierra?

    Visitors often explore the Guembe Biocenter, stroll around Plaza 24 de Septiembre, shop at La Recova Market, or take a tour of the Cathedral of Santa Cruz. Outdoor enthusiasts frequently choose to visit the Santa Cruz Zoo or the Botanical Gardens.

  • What is the best time of year to visit Santa Cruz de la Sierra?

    The most frequented time to visit Santa Cruz de la Sierra is during the dry season from April to October. The International Baroque Music Festival in April and the Santa Cruz Carnival in February are popular local events.

  • What are the best places to stay in Santa Cruz de la Sierra?

    Many visitors choose to stay in areas such as Equipetrol, a modern, upscale neighborhood, or the city center with its colonial architecture and vibrant markets. For a quieter stay, Urubó is a residential area with lush green spaces.

  • What are the best places to visit in Santa Cruz de la Sierra?

    Visitors often explore the Metropolitan Cathedral, the Noel Kempff Mercado Museum, and the Artecampo Gallery. The Jardín de las Delicias water park and the Arenal Park are also frequently suggested spots.

  • What are some hiking trails in Santa Cruz de la Sierra?

    Although Santa Cruz de la Sierra is largely flat, the Amboró National Park, about a two-hour drive from the city, has numerous hiking trails through diverse ecosystems, including rainforest and cloud forest.

  • What are some family activities to do in Santa Cruz de la Sierra?

    Families usually enjoy a day at the Guembe Biocenter with its butterfly house and orchidarium, exploring the Santa Cruz Zoo, or picnicking at the Lomas de Arena Regional Park. A visit to the Interactive Science Museum can also be fun for kids.

  • What are some of the best day trip ideas in Santa Cruz de la Sierra?

    Popular day trips from Santa Cruz de la Sierra include exploring the diverse flora and fauna at Amboró National Park, visiting the Jesuit Missions of Chiquitos, or discovering the sand dunes at Lomas de Arena Regional Park.

  • How much does it cost to stay in guesthouse rentals in Santa Cruz de la Sierra?

    Experience the best of Santa Cruz de la Sierra with our guesthouse rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there Santa Cruz de la Sierra vacation rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 2,210 vacation homes with pools in Santa Cruz de la Sierra, available on Airbnb. Make a splash and soak up the sun in style!

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