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Hotel vacation rentals in Los Santos Province
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Los Santos Province
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Los Santos Province hotel rentals
Family-friendly hotel rentals
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Private room in Tonosí
El Ranchito Family Room
![](https://a0.muscache.com/im/pictures/miso/Hosting-21713841/original/10fc682a-6678-473a-87ed-2a5ed56398e8.jpeg?im_w=720)
Hotel room in Playa Venao
4.88 out of 5 average rating, 8 reviewsMarea - Ocean View Room with King Sized Bed
![](https://a0.muscache.com/im/pictures/miso/Hosting-21699648/original/3885d931-e8de-4bad-a504-89da2135fc67.jpeg?im_w=720)
Private room in Playa Venao
4.67 out of 5 average rating, 9 reviewsArena Room - Family Room, Incredible Ocean Views
![](https://a0.muscache.com/im/pictures/miso/Hosting-21701291/original/9bc595b9-c870-476f-98eb-ec104f72b005.jpeg?im_w=720)
Hotel room in Playa Venao
5 out of 5 average rating, 9 reviewsBrisa - Ocean Views, Calm Vibes, King/Twin beds
![](https://a0.muscache.com/im/pictures/miso/Hosting-21700420/original/eeea4664-2e0c-4964-8dfa-c34f84cf30cb.jpeg?im_w=720)
Hotel room in Playa Venao
4.6 out of 5 average rating, 10 reviewsPlaya Room - First floor family space, ocean views
Hotel rentals with a pool
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Hotel room in La Arena
4.4 out of 5 average rating, 5 reviewsFaranda Guayacanes Chitré - Queen Bed - Tarifa Estándar SA
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Hotel room in La Arena
Hotel Cubitá, Panama
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Hotel room in Las Escobas del Venado
4.2 out of 5 average rating, 5 reviewsSelina River Venao - Standard Room
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Hotel room in Las Tablas Abajo
4.78 out of 5 average rating, 9 reviewsGreen Room Trio - 3 at the Beach!
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Hotel room in Las Tablas Abajo
4.58 out of 5 average rating, 12 reviewsYellow Room, Deluxe Suite for 4
![](https://a0.muscache.com/im/pictures/miso/Hosting-40968706/original/6c7af80c-a283-4122-b5c2-9101c6d159fb.jpeg?im_w=720)
Hotel room in Playa Venao
Garden View Private Room @ Villa Marina
![](https://a0.muscache.com/im/pictures/fff8c436-f1fa-40d4-b119-db32e7b2fa15.jpg?im_w=720)
Hotel room in Playa Venao
Ocean View Double Bed Private Room @ Villa Marina
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Hotel room in Panama City
One Bed Private Room @ Villa Marina
Hotel rentals with a patio
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Hotel room in Santo Domingo
Hotel La Luna Playa Uberito
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Hotel room in Pedasí
Hotel Carey
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Private room in Guararé
Hostal Villas de Zianit en el Jobo de Guarare,
![](https://a0.muscache.com/im/pictures/5166f370-f287-4935-97f8-55a27a84d91a.jpg?im_w=720)
Hotel room in La Enea
4.87 out of 5 average rating, 15 reviews2nd floor room for up to 6 people!
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6NjA4Njc1MzEyNzc5NjcxNTAz/original/f247b7e5-abd0-41e1-8ee6-b6c151b0d451.jpeg?im_w=720)
Private room in Las Tablas
4.86 out of 5 average rating, 7 reviewsHotel Villas Don Pablo / Las Tablas Villa N°1
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Private room in Las Tablas
4.71 out of 5 average rating, 7 reviewsHotel Villas Don Pablo / Las Tablas Villa N°2
![](https://a0.muscache.com/im/pictures/c8f30b53-373e-4d0d-b36d-37064fb54015.jpg?im_w=720)
Private room in Pedasí
4.69 out of 5 average rating, 26 reviewsRoyal Suite - CASA WABI SABI
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Private room in Pocrí
4.57 out of 5 average rating, 7 reviewsCharming SIMBA Room! Casa Wabi Sabi
Destinations to explore
- Boutique hotel rentals Panama
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- Monthly Rentals Los Santos Province
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