Villa vacation rentals in Panama City

Find and book unique villas on Airbnb

Top-rated villa rentals in Panama City

Guests agree: these villas are highly rated for location, cleanliness, and more.

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Guest favorite

Villa in Chame

4.84 out of 5 average rating, 178 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide.

Guest favorite

Villa in Panamá

4.98 out of 5 average rating, 45 reviews

Breathtaking Views Mansion w/King Beds

Book your next thrilling Panama City vacation at our dreamy 11,500 sq. foot multi-story family mansion, superbly located on a hilltop high above the metropolis in this affluent neighborhood. Ideal for longer stays. Discover the vibrant buzz of Cinta Costera or explore the UNESCO world heritage sites at Casco Viejo – all under 5 km away from your doorstep. Enjoy a refreshing dip into the swimming pool and admire the sublime views of the Panama City Skyline from our unique roof terrace.

Guest favorite

Villa in Punta Pacifica

4.98 out of 5 average rating, 64 reviews

Beautiful House in Panama w/ King Beds + Pool

Welcome to our stunning home located in the heart of Punta Paitilla, Panama. This beautiful property boasts 4 bedrooms, 3.5 bathrooms, 7 beds, and can comfortably accommodate up to 11 guests, making it the perfect choice for families or groups of friends. This property also features a private outdoor pool, where you can soak up the sun and cool off on hot days. For those who like to stay active, there is a gym on-site where you can work out and stay in shape during your stay.

Superhost

Villa in Panamá

4.77 out of 5 average rating, 44 reviews

Villa La Vista-Panama's majestic mountain hideaway

Welcome to our Villa in Panama's Chagres National Park! Breathtaking views of the surrounding mountain range. Take in the beauty of the mountains and cityscape. Take a dip in our stunning infinity pool, offering picturesque landscapes. Ultimate relaxation during sunset evenings in our inviting hot tub. A gym station you can stay fit. Jefferys Tamarin monkeys at our feeding station. Unwind in a hammock or enjoy a romantic poolside swing. Relax on the outdoor bar stools.

Guest favorite

Villa in Portobelo

5 out of 5 average rating, 55 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Guest favorite

Villa in Punta Chame

4.99 out of 5 average rating, 110 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Guest favorite

Villa in Playa Coronado

4.98 out of 5 average rating, 119 reviews

Magnificent beach house in Coronado

House with 3 large bedrooms with air conditioning and fans, 3 bathrooms, dining room with air conditioning and fan, pool, large kitchen, spacious terrace with fans, large garden, BBQ area with complimentary gas, modern decor, ping pong table, a few meters from serene beach, front and rear entrance, parking inside and outside the house, Wi-Fi, cable and webTV, pool floats and more. House is nearby perimeter and front and back walls, it's pet friendly

Guest favorite

Villa in San José

4.82 out of 5 average rating, 44 reviews

The Luxury Mini Resort House Sol @Punta Barco

Welcome to the Mini Resort Verano Sol with capacity for 12 people with optional food catering. Just 1 minute from the beach, this cozy house has 4 bedrooms, private terrace, trampoline, free Netflix, jacuzzi, swimming pool, bbq, integrated sound system, hamaca, hotel beds quality, fast wifi, inspired by a mural of the famous artist @remedios_art. This is a great house for vacations, celebrations or productions. We are pet friendly! Book Now

Superhost

Villa in Juan Gallego

4.85 out of 5 average rating, 13 reviews

Fantastic KasaKai Villa

Nestled as the prime choice for beachfront living near Panama City, this exclusive Villa boasts unparalleled views of the Caribbean Sea. With a private entrance to the sea and a verdant green area for relaxation or private barbecues, it offers the epitome of luxury for discerning guests seeking a nature-infused escape. Perfectly blending tranquility with top-tier amenities, it's an oasis for those craving the serenity of waterfront living.

Guest favorite

Villa in Chame District

5 out of 5 average rating, 11 reviews

Villa at Caracol Beach 3 bed (V4-PBA)

¡Welcome to your perfect beach getaway! This charming ground-floor villa awaits you just 100 meters from the golden sand and refreshing waves of the sea. This home offers an ideal retreat for families and groups of friends looking to relax and enjoy the sun and sea breeze. Enjoy the pool right in front of the villa, where you'll also find a playground for everyone to enjoy. ¡Book now and experience a dreamy seaside vacation!

Guest favorite

Villa in Maria Chiquita

4.9 out of 5 average rating, 69 reviews

Villa en Playa Escondida Resort

Playa hidden Resort & Marina, is a jewel of the Caribbean , one of the most beautiful and exclusive beaches, one hour from Panama City or the Airport , located in Maria Chiquita, Columbus. The project is growing , currently there are constructions in development. Our exclusive Villa , has a terrace with BBQ, natural temperature Jacuzzi and low pumping system, direct access to the pool and a 1 mint walk to the beach .

Guest favorite

Villa in Cacique

5 out of 5 average rating, 30 reviews

Cacique SEA FACE (Portobello Park)

In the middle of the Parque National de Portobello (access only in 4x4, 4DW), nestled at the top of the hill, between sky and sea, out of sight, at the forefront, a cozy little love nest very private to rest and disconnect (as a couple or with friends), comfortable, bright (large and high glass windows), spacious, cool (central air conditioning), witness of a grandiose spectacle waiting for you...!