House vacation rentals in DeSoto County

Find and book unique houses on Airbnb

Top-rated house rentals in DeSoto County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Sebring

4.98 out of 5 average rating, 320 reviews

Chill and Relax at the Little White House

Cozy and inviting house,recently renovated with modern and old touches which has one bedroom and two full size beds.Also a small area where you can relax and read a book or use as a dressing room since is located next to the bathroom and bedroom.Office space with a desk,printer and all you need for your business trip.On the back there's a nice covered patio where you can relax and have a nice time.The house is centrally located,close to supermarkets,shopping,etc.Two minutes drive to Lake Beaches

Guest favorite

Home in Lake Placid

4.89 out of 5 average rating, 176 reviews

Lake Huntley Oasis - Pvt Dock - 1/2 Acre - Kayak

Live the lake life! Watch the sun set over Lake Huntley from your kitchen window and firepit; explore the lake by docking your watercraft (or rent ours) in your backyard, or use our included tandem kayak, canoe, SUP. This cozy house has 3 bedrooms, 2 bathrooms and sleeps up to 9 comfortably. Enjoy plenty of living space, a large screened-in porch, full kitchen, fire pit and BBQ grills. The house also includes onsite laundry, EV charger, RV hookup & parking. Kitchen completely renovated in 2024!

Guest favorite

Home in Punta Gorda

4.96 out of 5 average rating, 228 reviews

Tropical getaway Pool and tiki bar

1)Beautiful newer build house on 2 acres 1800sq/ft with 3 BR and 2 bath sleeps up to 8. 2)Has a large above ground pool 18' x 33' and a large fish pond and outdoor bar/BBQ and tropical landscape parking for 4 cars. 3)15mins drive from downtown Punta Gorda with lots of great restaurants little shops and bars with live music and much more, 7mins drive closest store winn-dixie. 4)10 mins drive to Punta Gorda airport. Located in a peaceful neighborhood with large oak trees on a dead end street.

Guest favorite

Home in Punta Gorda

4.95 out of 5 average rating, 144 reviews

Seasonal vacation rental with Heated pool

The living room has a 65 " smart TV,wall mounted with a LCD Fireplace below with surround sound- All TV's have Netflix.The bar room has a small refrigerator,pool table and dart board.Outside has a private lanai with Heated pool and a propane firepit.Enjoy the sonos sound with 55" smart TV in the Master bedroom the second bedroom also has a TV. The bar room,also has sonos as well as the lanai.30 minutes from several beaches.The garage will not be available.Home located in a quiet Cul de Sac

Guest favorite

Home in Sarasota

4.96 out of 5 average rating, 142 reviews

Sarasota Florida -Wild Orchid Creek Cottage Home

Come enjoy old Florida living at this completely renovated cottage style home on nearly seven acres. Relax and unwind in this 1000 square foot private home with king bed and queen sleeper to accommodate up to four people. Open concept living, dining room and full kitchen. Laundry facilities available. Equipped with WiFi and direct tv. While enjoying the private backyard space, it is common to spot abundant wildlife and wildflowers. Wild orchids in many of the oak trees bloom in early summer.

Guest favorite

Home in Port Charlotte

4.97 out of 5 average rating, 156 reviews

Cute comfy clean canal home fishing wildlife 3B/2B

Our Airbnb is the perfect place to relax. It’s a great space to play games or watch a movie. It has a nice Florida room that overlooks our fresh water canal or grab a chair and head down to the canal to chill or fish! We are only 11 miles from Punta Gorda airport, about 30 min to the beautiful Englewood beach or Boca Grande beach or only 55 min to Siesta Key Beach. Or enjoy Port Charlotte Beach Park with a small beach, pool, boat launch and playground which is only 5 miles from our Airbnb.

Guest favorite

Home in North Port

4.97 out of 5 average rating, 118 reviews

Cozy & Beautiful Pool Villa in Sarasota County, Fl

Welcome to our home! It’s our pleasure to host you! Your family & friends will be close to everything when you stay at this centrally-located place: shopping, dining, beaches, entertainment, Warm Mineral Springs, Aquatic Center, etc. This charming house located in a beautiful & quiet neighborhood, tastefully furnished & decorated, fenced for your privacy & perfect for making memories with family & friends. Plenty of amenities to make your stay as comfortable as possible. Great location.

Guest favorite

Home in North Port

4.9 out of 5 average rating, 117 reviews

Private Small Vacation House

Enjoy the entire small 3 bedroom house 25 minutes from beaches. 5 minutes to Warm Mineral Springs. No service fee and free early check-in or late check-out maybe available. Free use of laundry room, beach and kitchen essentials included with your stay. TV with Roku in every room. Front bedroom: Full-size bed (Sleeps 2) Back bedroom; Queen size bed (Sleeps 2) Bonus room: (Private AC) Queen size bed (Sleeps 2) Livingroom: Queen size sleeper couch (Sleeps 2) No Parties or events

Guest favorite

Home in Myakka City

4.98 out of 5 average rating, 146 reviews

Charming Country Stay (Near Lakewood Ranch)

Named one of "Sarasota Area's Favorite Airbnbs" by Sarasota Magazine September 2021! Enjoy solitude in a country setting but have access to many activities, restaurants, and amenities only 10 minutes away in Lakewood Ranch community. The Guesthouse is a 40 minute drive to several wonderful beaches, including beautiful Siesta Key. Other nearby places of interests include UTC Shopping District, Hunsader Farms, TreeUmph and Ellenton Outlet Mall, Myakka State Park, and Celery Fields.

Guest favorite

Home in Port Charlotte

4.84 out of 5 average rating, 161 reviews

Reduced Rates on this waterfront property

REDUCED PRICE - Our home is in small quiet neighborhood and completely ready for your vacation, extended stay, or work away from home. We are located on a canal with a dock with quick access to the Peace River and the intracoastal waterway via boat. There are many local restaurants, activities, and fun things to do. Watch the sunset from your dock or take a 5 minute car ride to Punta Gorda to watch from numerous local restaurants on the water.

Guest favorite

Home in Lake Placid

4.95 out of 5 average rating, 154 reviews

Lake Beach 6 Bedroom, 4 Bath, plus 3rd floor bonus

Experience the beauty of lake life with this 7-bedroom (one is the third floor that does not have a door) lakefront, over 4000 square foot home! Play along the white sandy beach, enjoy the view from the screened-in patio with outdoor kitchen or watch the stars as you take a soak in your own private hot tub on the second floor balcony! This home is newly renovated and perfectly designed to accommodate you and all of your family and friends.

Guest favorite

Home in Avon Park

4.94 out of 5 average rating, 209 reviews

Lake Letta Lakehouse

This is a great lakefront home on beautiful Lake Letta a 478 acre lake. Face west for beautiful sunsets and great view of undeveloped land nature at it's best. The home is very open and spacious with family room, with wet bar, beautiful stone fireplace, and mid-sized pool table. Xfinity internet is also offered, as well as you tube tv and Amazon Prime streaming packages.