Guesthouse vacation rentals in Lee County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lee County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Lee County guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Fort Myers
4.81 out of 5 average rating, 54 reviewsQuiet Area close to Beaches, shopping and FGCU
Guesthouse in Fort Myers
4.92 out of 5 average rating, 105 reviewsThe Hummingbird House: life's simple pleasures!
Guesthouse in Fort Myers
4.97 out of 5 average rating, 282 reviewsChameleon Guest Cabana
Guesthouse in Fort Myers
4.98 out of 5 average rating, 624 reviewsHints of Key West in Fort Myers' Historic District
Guest house rentals with a patio
Guesthouse in Cape Coral
4.89 out of 5 average rating, 19 reviewsrelaxation house
Guesthouse in Fort Myers
5 out of 5 average rating, 16 reviewsTropical Oasis Loft
Guesthouse in Alva
4.77 out of 5 average rating, 26 reviewsCharming Alva Efficiency
Guesthouse in Fort Myers
4.83 out of 5 average rating, 46 reviews"Arlington Rental" Your Affordable Guesthouse
Guesthouse in Bonita Springs
5 out of 5 average rating, 32 reviewsBeachy Airstream Oasis with Bikes
Guesthouse in Bonita Springs
4.93 out of 5 average rating, 15 reviewsHouse by the river
Guesthouse in Fort Myers
4.92 out of 5 average rating, 13 reviewsDowntown Fort Myers Florida - Home Away From Home
Guesthouse in Bonita Springs
5 out of 5 average rating, 11 reviewsSpacious 1 Bedroom Suite
Guest house rentals with a washer and dryer
Guesthouse in Saint James City
4.97 out of 5 average rating, 78 reviewsWaterfront island suite with private pool & kayaks
Guesthouse in Fort Myers
5 out of 5 average rating, 70 reviewsGuesthouse
Guesthouse in Estero
4.9 out of 5 average rating, 29 reviewsAdorable Cottage with Heated Pool -Jaccuzi - Sauna
Guesthouse in Fort Myers Beach
4.95 out of 5 average rating, 19 reviewsLil Lavender
Guesthouse in Fort Myers
5 out of 5 average rating, 72 reviewsCharming Carriage House in Historic Neighbourhood
Guesthouse in Cape Coral
5 out of 5 average rating, 12 reviewsLuxury on the Lake
Guesthouse in Fort Myers
4.86 out of 5 average rating, 7 reviewsLa Casita: Guest House with amazing pool
Guesthouse in North Fort Myers
4.97 out of 5 average rating, 32 reviewsFish, Hunt, Sleep, Repeat!
Destinations to explore
- House rentals United States
- Guesthouse rentals United States
- House rentals Florida
- Guesthouse rentals Florida
- House rentals Florida
- Guesthouse rentals Florida
- Guesthouse rentals Tampa
- House rentals Tampa
- House rentals Naples
- Guesthouse rentals Naples
- Condo rentals Lee County
- Rentals with a kayak Lee County
- Fitness-friendly rentals Lee County
- House rentals Lee County
- Rentals with outdoor seating Lee County
- Rentals with an accessible height toilet Lee County
- Rentals with pools Lee County
- Rentals with lake access Lee County
- Kid-friendly rentals Lee County
- Family-friendly rentals Lee County
- Rentals with a patio Lee County
- Rentals with breakfast Lee County
- Rentals with beach access Lee County
- Hotel rentals Lee County
- Rentals with a washer and dryer Lee County
- Tiny house rentals Lee County
- Monthly Rentals Lee County
- Townhouse rentals Lee County
- Waterfront rentals Lee County
- Rentals with a fireplace Lee County
- Villa rentals Lee County
- Rentals with a fire pit Lee County
- Pet-friendly rentals Lee County
- Rentals with a hot tub Lee County
- Bungalow rentals Lee County
- Cottage rentals Lee County
- Beachfront rentals Lee County
- Private suite rentals Lee County
- Smoking-friendly rentals Lee County
- Apartment rentals Lee County
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes