Boutique hotel vacation rentals in Missouri

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Missouri

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Hotel room in Washington

4.95 out of 5 average rating, 115 reviews

River Sirens Hotel Deluxe Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Every room as a very large balcony with river views. Each room is also equipped with a full kitchen featuring large refrigerators w/ ice dispensers, induction stove top, microwave, toaster, and coffee station.

Guest favorite

Hotel room in Osceola

4.92 out of 5 average rating, 88 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Guest favorite

Hotel room in Springfield

4.95 out of 5 average rating, 191 reviews

“Camp Rockwood”at Rockwood Motor Court on Route 66

Rockwood Motor Court, on historic Route 66, was built in 1929. Each room is themed and furnished to the era of Route 66. Camp Rockwood pays homage to the important history of motor courts along the road. It is decorated with historic photos of Rockwood and other courts and motels. Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We have larger rooms or can package multiple rooms for your group.

Guest favorite

Hotel room in Excelsior Springs

4.93 out of 5 average rating, 15 reviews

Beautiful Historic Suite

The Hope Loft Suite, located on the second floor of Casa Di Vite International Wine Café," in Excelsior Springs, Missouri, offers a delightful place to stay. This exquisitely furnished loft is crafted to reflect the style of the early 1900s, featuring a generous king-size bed and an additional room with a twin-size bed. Its location in historic downtown Excelsior Springs ensures easy access to diverse dining choices and shopping experiences. A private staircase in the back offers access.

Guest favorite

Hotel room in St. Louis

4.87 out of 5 average rating, 681 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Guest favorite

Hotel room in Hannibal

4.96 out of 5 average rating, 112 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Guest favorite

Hotel room in Hollister

4.91 out of 5 average rating, 88 reviews

Vintage Creekside Motel in Hollister MO (09)

Enjoy easy access to popular shops and restaurants from this charming vintage hotel in Downtown Hollister. We are also only one mile from Branson Landing/downtown Branson. Room 9 is on the front of the building and is a walk in unit. There is a queen bed in the front room and a king bed in the back room where the bathroom is. There is a wet bar area with a fridge, microwave, coffee pot, keurig, and a few plates, bowls, cups, mugs, and utensils. We prove the coffee and creamer.

Guest favorite

Hotel room in St. Louis

5 out of 5 average rating, 16 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

The Riverfront Suite is a luxurious escape in the heart of St. Louis. As one of 4 rooms in our church-converted-inn, it is adorned with exotic wood finishing, stained-glass windows and gothic inspired architecture. Embellished with a plush queen bed, captivating stained glass windows, and a private en-suite bathroom with heated floors. Don't miss out on shared access to the rooftop hot tub for ultimate relaxation! Perfect for a romantic getaway or a tranquil retreat.

Guest favorite

Hotel room in Eldon

4.95 out of 5 average rating, 41 reviews

#8 A 1930’s Motor Court, Historic Randles Court

Family owned and operated! Built in the early 1930s, our recently restored rooms will take you back to simple times. The days of bus & railway rest stops, road-trips in the family car, and the quintessential motor court. Our town is alive with new and old businesses alike - places to eat, shop, and play for everyone in the family! We’re centrally located in downtown Eldon-just 15 minutes from the Lake of the Ozarks and 30 minutes from Jefferson City.

Guest favorite

Hotel room in Perryville

5 out of 5 average rating, 6 reviews

The Atrium - A Boutique Hotel - Suite 17

The Atrium is a historic building located in downtown Perryville, MO that has recently been beautifully rehabbed. Each room is a new experience. Spend your time resting and recharging in your private room, playing pool/socializing in the community lounge, or getting some fresh air in the outdoor courtyard. *DIsclaimer* The Atrium is located right next to the local downtown night life, so you may hear noise between the hours of 10:30pm-1:30am.

Guest favorite

Hotel room in Seneca

4.88 out of 5 average rating, 17 reviews

The Den Suite

Cozy, country, and charming in the open floor plan of The Den. Guests will be able to enjoy the comforts of Small Town America; while, being minutes away from local attractions. Queen Log Bed sleeps 2 guest, kitchenette (stocked with dishes, coffee maker, and microwave), and includes such amenities as guest-controlled A/C and Heat, Wi-Fi access, Smart TV, and more!

Superhost

Hotel room in Washington

4.87 out of 5 average rating, 156 reviews

430 West Front: Balcony Riverfront View

This room is located on the second floor over our quaint wine bar with a private balcony overlooking the Missouri River. Enjoy a cup of coffee or glass of wine from our wine bar on your private balcony. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.