House vacation rentals in St. Charles County

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Top-rated house rentals in St. Charles County

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Guest favorite

Home in Saint Charles

4.95 out of 5 average rating, 248 reviews

*HotTub* The Jewel on 5th-2br2b-near Historic Main

A true gem 15 mins from St Louis Lambert Airport-enjoy a well equipped, century home with a short walk to Historic Main and a HOTTUB. The large stocked kitchen is great for entertaining. Master bedrm w/luxurious, king sized, 4 poster bed and ensuite bathrm awaits you. In the private, queen suite you’ll find its own bathrm and another door leading onto the deck. The chair off the kitchen folds out to a standard twin and bedding is provided for the sofa as well. This charming jewel accommodates 6.

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 242 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Guest favorite

Home in Granite City

4.96 out of 5 average rating, 161 reviews

Cozy 2-bedroom home minutes from ST. Louis, MO

Welcome to the Sheridan House. This cozy 2-bedroom home is located in a quiet neighborhood. It sets on a corner lot with a large back yard and a parkway across the street. Spend relaxing evenings on the patio, grilling your dinner. Or challenge your partner to a game of ping pong in the basement rec room. Centrally located, you can spend your days exploring attractions in Saint Louis, Mo, Alton and Edwardsville, IL. Just minutes from World Wide Technology Raceway, Busch Stadium, & the Arch.

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 549 reviews

301 Guesthouse- Historic Main street-Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Guest favorite

Home in Saint Charles

4.88 out of 5 average rating, 189 reviews

Aunt Doodle’s House 8 blocks from Historic Main St

The cozy home is only 8 blocks from Historic Main Street. Is easily accessible to the high lights of St. Charles. Main Street has fantastic night life as well as great food. It is cheap to Uber back and forth from a very busy area of St. Charles. The Ameristar Casino is 1.5 miles from the residence. Hollywood Amphitheater/Casino is also 4.2 miles away. There are always activities to be found in the surrounding areas as well. This home has been in same family since was built new in 1953.

Guest favorite

Home in Saint Charles

4.96 out of 5 average rating, 216 reviews

Sweet Escape Near Historic Main Street & MO River

Find a sweet escape in a cozy bungalow! Walk to Main Street in 15 minutes! This 4-bedroom house is the perfect location to explore St. Charles & St. Louis. Historic Main Street has shops, restaurants, & events on a cobblestone street. The semi-finished basement is a game-room with a pool table, ping-pong, foosball, & darts! There are board games & DVD’s as well. Outside, you have yard games & a fire pit! Comfortable beds with plush bedding & room-darkening curtains will ensure a restful night.

Guest favorite

Home in Saint Charles

4.93 out of 5 average rating, 136 reviews

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

New Carpet! Adorable turn of the century home is located in Midtown St. Charles Historic District and sleeps 7. You won’t want to miss this St. Charles Charmer! Updated, fully stocked kitchen, dining room with Keurig coffee bar, living room w/75" SmartTV and plenty of seating throughout, SmartTV in 2 Bedrooms, 2 full bath, washer & dryer, outdoor gazebo w/table & chairs. Street & driveway parking. Close to area attractions: Historic Main Street, Ameristar Casino, & Lindenwood University.

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 122 reviews

Charming 2/1 in St Charles Historic Main Street

Come relax and play! Half a block from historic Main Street in City of St Charles. This stay is everything you could want. Cozy, charming, private with outdoor area for seating and dinning table. Off-street parking, laundry. Go shopping in the historic downtown shops, go to concerts, casinos or just stay in and enjoy! Walk to restaurants and the Katy Trail! Come be our guest! Or stay in put and cook the kitchen has everything you need! We are a strictly non smoking stay, inside or outside.

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 155 reviews

★ Blissful Historic Home Near Main St. ST CHARLES★

When you stay at this centrally-located 90 year old home, your family will be minutes from Historic Main Street St. Charles, and entertainment available in the new Streets of St. Charles. Restaurants, Movie Theaters, shops, and boutiques. The home is located near I-70, Hwy 94/364, and it is 25 minutes from downtown St. Louis, where you can visit the St. Louis Arch, the City Museum, or visit the amazing St. Louis Zoo! You may consider attending a St. Louis Cardinals, or Blues Hockey Game.

Guest favorite

Home in Saint Charles

4.99 out of 5 average rating, 177 reviews

Charming Bungalow in Historic St. Charles, MO

This charming bungalow is located in the heart of Historic St. Charles, Missouri. Just blocks from Historic Main Street where you can enjoy dining & shopping from a variety of local businesses, as well as Frontier Park & the Katy Trail which are perfect for a stroll or bike ride! The bungalow is steps away from Lindenwood University, a short drive to Streets of St. Charles & Ameristar Casino, a 15 minute drive to St. Louis Lambert Airport, and a 30 minute drive to downtown St. Louis!

Guest favorite

Home in Saint Charles

4.9 out of 5 average rating, 202 reviews

Tompkins Street Retreat

Relax in this 2 bedroom, 2 bath house with backyard patio and firepit with privacy fence. Walk to unique shopping and entertainment on Historic St. Charles Main Street. Augusta wineries and St Louis area attractions are a short drive away. Enjoy the comfortable living room with large TV, the fully equipped kitchen for special meals. Unwind after an active day with a meal under the pergola and drinks around the fire pit. The spacious main bedroom is perfect for a quiet restful night.

Guest favorite

Home in Saint Charles

4.97 out of 5 average rating, 224 reviews

Bright & Cozy Shotgun DPX 1 Block from Historic DT

Admire this unique historic home's design with brand new amenities and antique details that give a fresh and charming feel. Built in the 1930's, this half of the duplex has a typical shotgun layout with ten-foot ceilings giving a spacious feel. The front door leads directly to the living room, then into the bedroom, both of which have the original hard wood floors. The back of the house has the kitchen, with exposed brick, a dining area, and a bathroom with a washer and dryer.