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Family-friendly vacation rentals in Mesa County

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Mesa County

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Farm stay in Glade Park

4.87 out of 5 average rating, 561 reviews

Cozy Rustic Colorado Cabin!

Cozy Rustic Cabin, located on a working horse ranch on top of the Colorado National Monument, 30 min from Grand Junction, CO. This location is perfect for those seeking a unique place to stay while enjoying all the adventures available around the area including hiking trails, horseback riding, ATV riding, hunting, and some of the best mountain biking around. There is beautiful aspen covered,alpine high country nearby as well as red rock desert/ formations including a series of natural arches.

Home in Paonia

4.95 out of 5 average rating, 174 reviews

Laura's Tower - Views, King, Pets, Private, Decks

Nestled on a hillside with unique sweeping views, the Tower is the perfect destination for romantic escapes, remote work & family or group getaways. Entire house is yours! Laundry included. The spacious two-story house boasts a versatile open floor plan and is designed for ultimate comfort. Upstairs, enjoy the sunny private deck, king-sized bed, twin sofa couch, office desk and a spacious bathroom with oversized bathtub. The well-equipped downstairs kitchen includes range & oven plus dishwasher.

Home in Grand Junction

4.89 out of 5 average rating, 248 reviews

Hill View in the Ridges

What you will find during your stay here? Awe-inspiring natural beauty of the Red Rocks of the Colorado National Monument. Exhilarating outdoor adventures including hiking, skiing. Hundreds of miles of world-class mountain biking trails such as Kokopelli Trail. Incredible whitewater rafting on the Colorado River. Stunning golf courses whose green fairways are juxtaposed against the craggy Redland desert. All with in miles of the Redlands Golf course, Lunch Loop bike trail and Two Rivers Winery.

Home in Grand Junction

4.92 out of 5 average rating, 173 reviews

5200SqFt, Hillside Rock In House, Stunning Views

One of a kind 4BR 3BA 5,200 sqft home. Stunning views of the CO Ntl Mnt and entire Grand Valley. Our grandpa, a home builder, designed this rustic house as a masterpiece for his family. He wanted it to be part of nature, so he fit it between trees and inside left exposed the massive sandstone slab on which it’s built. This large house has entertained our family and friends for generations, and we’re thrilled that now you can share it with yours, too. Be in nature but minutes from downtown!

Home in Grand Junction

4.99 out of 5 average rating, 167 reviews

Blue Door Farm Vacation Rental

Beautiful, sunny, and brand-new vacation rental in the heart of southwestern Colorado's peach and wine country. Blue Door Farm Vacation Rental LLC offers full accommodations for 1 to 6 guests, with sweeping views of the Grand Valley from the high desert to the Grand Mesa. It is a 15 minute drive to downtown Palisade and Grand Junction, and only 5 minutes to one hour's drive to amazing year-round outdoor recreation, including hiking, biking, skiing, agritourism, music festivals and wineries.

Rental unit in Grand Junction

4.92 out of 5 average rating, 784 reviews

HOME AWAY HAVEN - Private Entrance

We welcome all, to settle into over 600 s.f. of above average basement living. LOCATED ON HIGHWAY 50 (we run parallel w/I-70), within a secured, gated 3/4 fenced property, 10 minutes from downtown Grand Junction. Two nice queen beds sleeping 4, couch w/recliners, futon, large electric reclining chair, twin & full inflatable mattresses, two sleep pads, full kitchen, 3/4 bath w/hot shower, nice towels, ample parking. Smart t.v. or Roku in bedrooms. WIFI Kids Under 3 Free All Smoking outside.

Guest suite in Grand Junction

4.84 out of 5 average rating, 140 reviews

Private Suite in Unique GJ Home !!

Recently remodeled suite in the lower level of my home! Great for long term traveling Medical Professionals! Private Bedroom/Living Room/Bathroom Suite in a convenient GJ location. Unique house, (Frank L Wright 'Usonian House'), wall of windows, suite opens to sub-level yard & patio. Close to CO Mesa Univ & St Mary's Hospital. Wi-fi, queen bed, desk, off street parking, and private entrance. Restaurants, shops & activities nearby. Using safe Covid practices! Accept guests over 25 yrs only.

Guest suite in Paonia

4.99 out of 5 average rating, 298 reviews

Very spacious private floor with beautiful views.

Self check-in to the space makes it especially convenient for travelers no matter when you arrive. Views of the surrounding mountains are breathtaking.Our place is good for couples, solo adventurers, and business travelers. The space is on your own floor, completely separated from our upstairs space and with a private entrance. Enjoy a self-serve continental breakfast with freshly ground coffee and an assortment of teas. The location is quiet and private, yet so close to town.

Barn in Palisade

4.9 out of 5 average rating, 568 reviews

Beautiful Vineyard Barn House

Our spacious and newly renovated large barn has a beautiful view of the Grand Valley. Relax among the vines under Mt. Garfield. Drink wine at one of the many wineries. Enjoy peace and quiet while picking a peach in the orchard or grapes in the vineyard. We are conveniently located 2 miles from downtown Palisade and 13 miles from downtown Grand Junction. From skiing, to mountain biking, to rafting, to hiking, and road biking there are outdoor activities nearby for all levels.

Bungalow in Palisade

4.71 out of 5 average rating, 374 reviews

Peachbowl Place

Our place has great views from the front porch, and fresh eggs every morning from the chickens in the back. A comfortable stay in the western Colorado’s famous wine country. The backyard is great for relaxing around a fire after exploring nearby parks, wineries, hikes, festivals, frisbee golf, brewery, distillery, dispensary, restaurants and quaint downtown. All just a short walk away. Come stay at your home away from home and experience our Western Hospitality.

Home in Paonia

4.73 out of 5 average rating, 284 reviews

Downtown n' Private

Location, Location, Location. Your B&B is one block from the bustling Paonia downtown! The house is spacious with a zest for the past and features one of the best covered patios in town! Summer gardens and privacy are what make this an excellent choice. For all you Verizon patrons your phone will squeak by here too. Take advantage of the furnished kitchen or enjoy the towns local fair. Your accommodations are flanked by Dons Market, and Sweetgrass cafe.

Cottage in Grand Junction

4.95 out of 5 average rating, 440 reviews

Gray Gables: Central Victorian with Romantic Flair

Welcome to our remodeled, thoughtfully decorated Victorian, romantic cottage! It boasts original hardwood floors & woodwork, quaint parlor, cozy porch, 2 townie bikes with locks, and a shed for recreational equipment. CMU & the Tabaguache Trail system are minutes away. Downtown GJ, the library, convention center, parks, Avalon Theater, & several churches are a short walk away.

Vacation rentals for every style

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Popular amenities for Mesa County family-friendly rentals

Free parking on premises

Air conditioning

Family-friendly home rentals with a hot tub

Rental unit in Grand Junction

4.85 out of 5 average rating, 440 reviews

Grand Valley Cozy Retreat

Guest suite in Crawford

4.97 out of 5 average rating, 589 reviews

Crawford’s Mountain View Getaway

Home in Grand Junction

4.96 out of 5 average rating, 150 reviews

Little Park Road Retreat - Hot Tub with a View

Home in Montrose

4.91 out of 5 average rating, 103 reviews

Stunning Views, Hot Tub, 7 BDRM 4 BTH

Family- and pet-friendly home rentals

Cabin in Cedaredge

4.78 out of 5 average rating, 37 reviews

Cabin #4 at Thunder Mountain Lodge

Home in Cedaredge

5 out of 5 average rating, 61 reviews

Gorgeous CedarGate House Cedaredge CO- Mountains!

Rental unit in Grand Junction

4.64 out of 5 average rating, 203 reviews

Cozy Studio

Home in Hotchkiss

4.95 out of 5 average rating, 164 reviews

The Moon House. Come mingle with the stars.

Yurt in Gateway

4.87 out of 5 average rating, 270 reviews

Unaweep Yurt and Thimble Rock (WiFi)

Home in Fruita

4.9 out of 5 average rating, 39 reviews

Juniper I: Dog Friendly & Large Patio!

Home in Palisade

4.8 out of 5 average rating, 112 reviews

The Magnolia House, Victorian Wine Retreat

Home in Paonia

4.94 out of 5 average rating, 136 reviews

Paonia Victorian Farmhouse

Family-friendly home rentals with a pool

Guest suite in Fruita

4.97 out of 5 average rating, 216 reviews

Bookcliff Ranch Casita

Rental unit in Grand Junction

4.91 out of 5 average rating, 79 reviews

St. Mary's Hospital Haven

Guest suite in Fruita

5 out of 5 average rating, 97 reviews

Western Colorado Bikers' Oasis

Condo in Grand Junction

4.92 out of 5 average rating, 12 reviews

Ideal Relaxing Location for Outdoor Adventurers

Destinations to explore