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House vacation rentals in Mesa County

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Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Home in Grand Junction

4.85 out of 5 average rating, 712 reviews

Happy Hippie House

Welcome to our beautiful, 1950 home known by our guests as the Happy Hippie House! Our home's interior has been updated, giving it a fresh, chic hippie vibe. The eclectic decor creates a light & airy interior. Come hang out on the front porch! Discover wineries, skiing, hiking, biking, kayaking & rafting. Minutes from CMU, hospitals, & a lovely downtown area. Free Wi-Fi & Roku w/Netflix. Electronic lock for easy late check-in. LGBT & 420 friendly (outside)! Earns 5 stars for convenient location.

Home in Paonia

4.95 out of 5 average rating, 174 reviews

Laura's Tower - Views, King, Pets, Private, Decks

Nestled on a hillside with unique sweeping views, the Tower is the perfect destination for romantic escapes, remote work & family or group getaways. Entire house is yours! Laundry included. The spacious two-story house boasts a versatile open floor plan and is designed for ultimate comfort. Upstairs, enjoy the sunny private deck, king-sized bed, twin sofa couch, office desk and a spacious bathroom with oversized bathtub. The well-equipped downstairs kitchen includes range & oven plus dishwasher.

Home in Orchard City

4.95 out of 5 average rating, 460 reviews

The Orchard House

**A devastating freeze in October 2020 killed all 400 of our sweet cherry trees and many of our peach trees. Sadly, our orchard is not the lush green jewel it once was. We are planting new cherry trees in the Spring of 2022. While the orchard views have changed, the Orchard House continues to offer a very comfortable place to rest and recharge. Come enjoy fresh air and quiet whether you are stopping through on a road trip or staying longer for local adventure. Fast WiFi for telecommuting!

Home in Grand Junction

4.97 out of 5 average rating, 159 reviews

Resort-like Adobe At Colorado Monument!

This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

Home in Loma

4.93 out of 5 average rating, 223 reviews

The Barn

THE BARN. This is a guest house on 10 acres surrounded by farmland. It has 3 bedrooms, 2 full bathrooms, a sofa bed, full kitchen and dining, full laundry set up and 2 car garage. We call it the barn because it looks like a barn and is frequently mistaken as a barn. A real wood fireplace in living room makes this a cozy place to stay. Large patio offers unrestricted views. Located just a few miles from town so you are close to the main attractions and trails. RV/trailer parking available.

Home in Grand Junction

4.92 out of 5 average rating, 238 reviews

Colorful 2 bedroom pet friendly home

Make some memories at this unique and family-friendly place. Our home welcomes you and your pet/s to enjoy our 2 newly decorated bedrooms with blackout curtains, remodeled luxurious bathroom with 2 showerheads, full kitchen , laundry, pet door, dog run, back porch to sit and relax, and lovely backyard to enjoy. We encourage you to walk downtown, only 6 blocks away. The Colorado National Monument, regional airport, CMU, library, Science Center for kids, and bike trails are very close.

Home in Grand Junction

4.95 out of 5 average rating, 349 reviews

🌞Sunny & Chíc🌞 Downtown Oasis

This is a unique, newly remodeled 1930's home just four blocks from downtown in a safe quiet neighborhood offering plentiful off street parking, a fenced in backyard, a large fully-stocked kitchen and spacious bedrooms with comfy memory foam beds. 1-2 miles to CMU, Lincoln Park and St Mary's Hospital. 10 min drive to the Lunch Loops mountain bike trail system and hiking and climbing in the Colorado National Monument. Please note this home is cooled with an evaporative cooler, not AC.

Home in Loma

5 out of 5 average rating, 498 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Home in Palisade

4.96 out of 5 average rating, 248 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Home in Grand Junction

4.98 out of 5 average rating, 119 reviews

Downtown! 2 blocks to Main Street! Art on White!

✨Art on White gives you an artistic, vintage, downtown experience with access to world-class mountain biking, wine tasting, vineyards and so much more! Our vintage home built in 1905, has quite a unique experience to offer. With love for our Community and Art in mind, we feature local artists and sculptors work throughout the home. This eclectic space provides a relaxing, whimsical, light & airy stay. We love this house and we hope you do too!! 😊

Home in Grand Junction

4.89 out of 5 average rating, 427 reviews

Memories On Main - GJ's Historic Downtown Home

When you step into this home, you’ll feel like you’ve stepped back in time! Lovingly preserved and tastefully updated, Memories on Main is a historic, Grand Junction home built in 1907. This vintage property has something to offer everyone. Hosts, Allie & Kevin are Grand Junction natives and are always just one call away to give advice on the best hiking and mountain biking trails, fantastic restaurants, activities, and more.

Home in Grand Junction

4.96 out of 5 average rating, 212 reviews

Downtown Launchpad for your Colorado Adventures!

Come experience a cozy, modernized historic home located in the growing and gritty mixed industrial/commercial/residential community near downtown Grand Junction, just blocks away from the Riverfront and Las Colonias Park. This convenient location does mean you will hear the TRAIN. However, 99+% of our guests don't even mention it (see our reviews)! The house sits on the same property as our strength and conditioning gym.

Vacation rentals for every style

Get the amount of space that is right for you

Cottages

Quaint homes, peaceful surroundings

Apartments

Convenient locations with everyday essentials

Cabins

Kick off your hiking boots at these rustic lodgings

Popular amenities for Mesa County house rentals

Free parking on premises

Air conditioning

House rentals with a pool

Home in Grand Junction

New place to stay

*New:Pool~HotTub~TikiBar~GameRoom~FirePit~MiniGolf

Home in Grand Junction

5 out of 5 average rating, 68 reviews

Pool, hot tub, views and close to everything

Home in Palisade

4.92 out of 5 average rating, 192 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Home in Fruita

4.89 out of 5 average rating, 27 reviews

Cozy House in Fruita, CO

Home in Palisade

4.81 out of 5 average rating, 59 reviews

Palisade Peach Orchard Farmhouse w/Pool & Spa 18+

Home in Grand Junction

4.79 out of 5 average rating, 33 reviews

Adventure Home Base - 7 Blocks to Downtown!

Home in Grand Junction

5 out of 5 average rating, 8 reviews

The Grant House

Weekly house rentals

Home in Grand Junction

4.95 out of 5 average rating, 142 reviews

Panoramic Views above the Colorado River

Home in Fruita

4.98 out of 5 average rating, 183 reviews

The Centennial House ~ Your Adventure Starts Here!

Home in Paonia

4.85 out of 5 average rating, 187 reviews

3rd Street Artists Retreat

Home in Grand Junction

4.92 out of 5 average rating, 173 reviews

5200SqFt, Hillside Rock In House, Stunning Views

Home in Grand Junction

4.99 out of 5 average rating, 167 reviews

Blue Door Farm Vacation Rental

Home in Grand Junction

4.93 out of 5 average rating, 240 reviews

Monument Paradise on golf course

Home in Grand Junction

4.84 out of 5 average rating, 67 reviews

Serene Riverwalk Retreat

Home in Fruita

4.89 out of 5 average rating, 151 reviews

Clean, Comfy, Best Patio in Fruita - dog friendly!

Private house rentals

Home in Crawford

4.99 out of 5 average rating, 87 reviews

Needle Rock View Retreat

Home in Montrose

4.95 out of 5 average rating, 63 reviews

Berg Haus-dog friendly, hot tub, remote friendly

Home in Palisade

4.96 out of 5 average rating, 67 reviews

Rapid Creek Retreat

Home in Palisade

5 out of 5 average rating, 79 reviews

Love Orchard

Home in Delta

5 out of 5 average rating, 19 reviews

Escalante Escape- It's home!

Home in Delta

4.84 out of 5 average rating, 25 reviews

Cottage

Home in Grand Junction

4.99 out of 5 average rating, 95 reviews

Cozy home minutes from downtown

Home in Grand Junction

4.97 out of 5 average rating, 38 reviews

Central Location: A/C, 13 acre park, CMU, Downtown

Destinations to explore