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Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guesthouse in Rancho Bernardo

4.92 out of 5 average rating, 701 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Guesthouse in Mission Hills

5 out of 5 average rating, 152 reviews

Santorini-Inspired Cottage #1 w/ Hot Tub + Views

Travel 16 steps up a Greek-inspired curving stairway with two-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the front private balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. Design & details inspired by European travel, it'll be hard to believe you’re still in San Diego.

Guesthouse in Sherman Heights

4.96 out of 5 average rating, 513 reviews

Romantic Private Garden Studio Near Downtown

A magical private garden surrounds a tiny studio (240 sq ft) with kitchenette in historic residential district, 10 blocks to East Village and Petco BallPark, near Gaslamp Quarter, and one mile to Convention Center and downtown. Easy access to freeways, very close to Balboa Park, San Diego Zoo, and Coronado Island. Airport and train station less than 15 min. We offer a safe, sweet, and contemplative getaway near the city, with WiFi but no TV. One pet OK only with prior approval. 420 friendly.

Guesthouse in La Mesa

5 out of 5 average rating, 217 reviews

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our casita is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Guesthouse in Solana Beach

4.98 out of 5 average rating, 457 reviews

Quiet cottage AC near beach in nice private yard.

Private cottage in a great neighborhood close to the beach. Cottage has an air conditioner/heater, queen bed, kitchen, bathroom, & TV & desk. Washer & dryer available. Fletcher cove is 1/2 mile by car or walk. Walking distance to Cedros Shopping district that has boutiques, restaurants & coffee houses. The Belly Up Tavern, Del Mar Race Track & Fairgrounds and fine restaurants are nearby. It is a short walk to the trailhead to San Elijo Lagoon Preserve hike and Annie's canyon.

Guesthouse in San Diego

4.97 out of 5 average rating, 329 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Guesthouse in Mira Mesa

4.96 out of 5 average rating, 160 reviews

super clean studio/private entrance&parking

Newly remodelled studio with private entrance and 1 reserved drive way parking spot in an upscale neighborhood. Bright color designs will bring you good mood and energy. Neighborhood is quiet and safe, near Sorrento valley, La Jolla and Del Mar beach. So many good restaurants and markets around. I'm an interior designer and really care about how my guests feel during their stays. When I designed and built this unit, I choose all unique materials that bring you the best experience.

Guesthouse in North Park

4.99 out of 5 average rating, 230 reviews

North Park Garden Retreat Casita

Nestled between the urban neighborhoods of North and South Park, our sanctuary within the heart of the city is surrounded by a secret garden that gives the impression of a tropical oasis. The private casita is tucked in the backyard of the Host’s home and has french doors which open to the lush greenery of the garden. Whether vacationing, traveling for work, or looking for an ideal space for relaxation and renewal, this is the perfect place to enjoy your San Diego stay.

Guesthouse in North Park

4.97 out of 5 average rating, 209 reviews

Fresh, hip and cozy private North Park guest house

Enjoy peaceful sunny San Diego days listening to the palm trees sway in this private backyard garden retreat set behind a 1925 California craftsman. The guest house is tucked away in a quiet quintessential Southern California neighborhood while only being a short and easy walk to amazing restaurants, world class breweries and cozy coffee shops. Balboa Park, the San Diego Zoo, beaches and downtown are all a few minutes drive away.

Guesthouse in North Park

4.91 out of 5 average rating, 910 reviews

Safe Private Sanctuary - TOWER STUDIO/ Northpark

Come to a sanctuary and enjoy the sun! Check-in is contactless. Enjoy your cozy and quiet tower studio with a private entrance, private full bathroom, and private upper deck. The studio house is in a large garden adjoining a craftsman-style house in the historic Northpark Morley Field District. Minutes away from coffee shops, breweries, Zoo, Balboa Park.

Guesthouse in North Park

4.99 out of 5 average rating, 272 reviews

Detached Private Studio Apartment with View

Private modern studio apartment in University Heights/North Park. Gorgeous canyon view deck overlooking Mission Valley. King temperpedic bed, new kitchen and bath, WiFi, Flatscreen and in ceiling surround sound. Close to restaurants, coffee, nightlife, freeway access, San Diego Zoo and Balboa Park. Private entrance. LGBT friendly.

Guesthouse in Pacific Beach

4.84 out of 5 average rating, 174 reviews

Mission Bay Coastal Studio | Steps to Beach & Bay

Welcome to The Wave, San Diego's best coastal & bayside studio retreat nestled in the coveted tip of Crown Point, San Diego. This well-appointed space offers a seamless blend of modern amenities, cozy comforts, and a design that fully embraces the coastal and surf culture of southern San Diego.

Vacation rentals for every style

Get the amount of space that is right for you

Cottages

Quaint homes, peaceful surroundings

Cabins

Kick off your hiking boots at these rustic lodgings

Apartments

Convenient locations with everyday essentials

Popular amenities for San Diego guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

Guesthouse in South Oceanside

4.97 out of 5 average rating, 547 reviews

The Flying Mermaid

Guesthouse in Mission Hills

4.92 out of 5 average rating, 393 reviews

La Casita - Fully Updated Casita in Mission Hills

Guesthouse in North Park

4.96 out of 5 average rating, 675 reviews

BEAUTIFUL Private Studio

Guesthouse in North Park

4.91 out of 5 average rating, 420 reviews

North Park Cottage

Guesthouse in La Jolla

4.93 out of 5 average rating, 534 reviews

Modern Surf Cottage

Guesthouse in Pacific Beach

4.78 out of 5 average rating, 379 reviews

Law Street Retreat

Guesthouse in Ocean Beach

4.8 out of 5 average rating, 338 reviews

Walking distance to Ocean Beach and Attractions !

Guesthouse in Leucadia

4.85 out of 5 average rating, 245 reviews

Sunset/Ocean View Guest House! Minutes to Beach

Guest house rentals with a patio

Guesthouse in Escondido

4.99 out of 5 average rating, 109 reviews

Garden Cottage

Guesthouse in Oceanside

4.95 out of 5 average rating, 192 reviews

Detached, Private Cottage! Fenced, PET friendly!

Guesthouse in Point Loma Peninsula

4.96 out of 5 average rating, 103 reviews

Sunset Cliffs Studio

Guesthouse in Sherman Heights

4.86 out of 5 average rating, 106 reviews

Cozy Downtown Cottage Minutes to Gaslamp & PETCO

Guesthouse in La Mesa

4.98 out of 5 average rating, 174 reviews

Da Hui Hut - La Mesa’s best view and spa

Guesthouse in Chula Vista

4.94 out of 5 average rating, 123 reviews

New! Beautiful Private Casita- King Bed & Office

Guesthouse in Golden Hill

4.97 out of 5 average rating, 131 reviews

Cozy Urban Casita! Near Gaslamp, Zoo and Coronado

Guesthouse in National City

4.97 out of 5 average rating, 141 reviews

Trendy 1 BR Guesthouse. Great views, no chores.

Guest house rentals with a washer and dryer

Guesthouse in Ocean Beach

4.96 out of 5 average rating, 253 reviews

Private beach guesthouse w/ private parking

Guesthouse in La Mesa

4.99 out of 5 average rating, 163 reviews

Stunning Guest House 15 min. from Zoo, Downtown

Guesthouse in Hillcrest

4.89 out of 5 average rating, 176 reviews

Relaxing Oasis - short walk to shops & recreation

Guesthouse in North Park

4.99 out of 5 average rating, 150 reviews

Carrie’s North Park Casita, in Heart of San Diego

Guesthouse in North Park

4.97 out of 5 average rating, 176 reviews

New Guest House - North Park

Guesthouse in Pacific Beach

4.86 out of 5 average rating, 233 reviews

Sea Star Cottage

Guesthouse in North Park

4.95 out of 5 average rating, 570 reviews

Early 1900's Carriage House w/Views

Guesthouse in El Cajon

4.98 out of 5 average rating, 206 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

Quick stats about guesthouse rentals in San Diego

Total rentals
1K properties
Total number of reviews
98K reviews
Family-friendly rentals
140 properties are a good fit for families
Pet-friendly rentals
250 properties allow pets
Rentals with a pool
90 properties have a pool
Rentals with dedicated workspaces
530 properties have a dedicated workspace

Destinations to explore