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Santee vacation rentals

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Top-rated vacation rentals in Santee

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Villa in Wild Dunes

5 out of 5 average rating, 3 reviews

New Listing! Lagoon Villa 34 - Top Floor Serenity!

Professionally managed by Deserving Vacations! Discover the charm of Isle of Palms at our top-floor Lagoon Villa 34! This cozy 2BR/2BA villa is perfect for small families or friends. Unwind in comfort after a day of island exploration! Super quick and simple 5 minute walk to the beach! Each bedroom has a full en suite bathroom and private balcony. This vacation rental provides easy access to all Wild Dunes shops, restaurants, spa, golf courses and biking/walking paths. Would love to host you!

Condo in Isle of Palms

4.95 out of 5 average rating, 106 reviews

1st Floor Spacious Condo Steps To Front Beach IOP

Oceanside Villas A103 Lovely updated Spacious 1st floor 2BR 2BA Modern Coastal Beach Villa, conveniently located across the street from Front Beach. Private direct beach and pier access. WIFI, 3 Smart TVS, pool and private fishing pier. Rent this villa or the one right beside it (A104) for your beach vacation with family or friends. Message me for details Enjoy the convenience of restaurants & popular IOP fun spots. supermarket, bars, pizza and ice cream shops all with in walking distance.

Home in Isle of Palms

4.93 out of 5 average rating, 91 reviews

Steps from the beach: extraordinary home and yard

-The beach a few steps away: wander down just 300ft and you will feel sand on your toes or just relax in the hot tub -Outdoor living: Achieving the indoor/outdoor lifestyle isn't exactly easy but this house does it! Perfect for lounging, lazy afternoons and outdoor dinner. In the colder month enjoy the fire pit, smores time anyone? - Additional attached apartment can be added for more space and comfort -Idyllic family escape: It displays charm, character, and luxurious comforts for all ages

Townhouse in Mount Pleasant

4.84 out of 5 average rating, 105 reviews

Luxury Townhouse with Charleston Coastal Cottage Flair

Beautifully remodeled townhouse in historic Old Village, of Mt. Pleasant, suburb of Charleston, SC. 2 miles from Sullivan's Beach and 10 minute drive to the Isles of Palms Beach. Centrally located, a 12 minute drive to downtown Charleston! Shem Creek is only minutes away full of great restaurants and shopping. Tucked away in a quiet cul-de-sac neighborhood, with a nearby farmers' market, plus great restaurants and stores. City/Town permit number: ST240184 City/Town permit number: 20129587

Home in Mount Pleasant

4.87 out of 5 average rating, 458 reviews

Beach+Downtown ★Walkable Old Village Luxury Style2

Best of Both worlds--3 minutes to Downtown Charleston & Sullivan's Island Beach! Mt Pleasant is Rated the Best Place to Live in SC! Enjoy Downtown Mt Pleasant Amenities. Old Mt. Pleasant in a Marsh-front Community. Beautiful 100 year-old Oak Trees! Walk to Shem Creek Restaurants & Marina, Steps to Old Village, Grocery stores, coffee shops, shopping, Red Drum Gastro Pub, New Mt P. Farmers Market. Relax in wonderful large private backyard under tree canopy. STR ST240049 BL: 20123990

Home in Ladson

4.9 out of 5 average rating, 160 reviews

Charleston HotTub FirePit FirePlace Patio Hammock

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ 2 mins to Summerville Medical Center ✅ Featured in Relative Race Reality TV show! ✅ 10 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 18 mins to Airport/Convention Center/Performing Arts ✅ 3 mins from Publix Grocery and restaurants ✅ Hot Tub 💦 ✅ Fire🔥Pit ✅ BBQ 🍔 Grill ✅ Fire🔥Place ✅ Hammock 🌴 ✅ High Chair & Pack n Play 🍼 ✅ Air Hockey Table 🏒 ✅ K Cup/Coffee Pot ☕️ ✅ Coffee/Decaf/Tea ☕️

Home in Isle of Palms

4.9 out of 5 average rating, 114 reviews

Amazing Location, across the st. from the beach!

Located directly across the st. from the beach, w/public access! Fully fenced, pet friendly. 4 bd - sleeps 10 comfortably, 2.5 bths. Bright open airy design. Huge living room w/high vaulted ceilings. Eat-in kitchen & newer appliances. Formal dining rm w/lots of glass & great views. 3 front porches-1 screened. 3 Decks. French doors in up. bds lead to outdoor sitting areas. Close to awesome restaurants, shopping, food stores & so much more! ONLY WEEK LONG MIN STAYS IN SUMMER

Home in Cannonborough - Elliottborough

4.98 out of 5 average rating, 132 reviews

❤️ of Charleston - Luxurious & Rustic -Near King!

Completely Renovated House - 1block from King Street! (Brand New Listing! - Rare Find!) * 3 bedrooms +2 full bunk beds & 2 full bathrooms * Brand new Construction - Heavily insulated and quiet inside! * High End Kitchen! * Walk Score 98 ('Very Walkable') * 1 Block From King Street * Private Outdoor Piazza + Outdoor Terrace * Off Street Parking for 2 vehicles * Onsite washer's & dryer's * Safe neighborhood in awesome location - near all the best restaurants and bars!

Home in Isle of Palms

4.97 out of 5 average rating, 101 reviews

Luxury Coastal Cottage With Pool

Experience Life in The Lowcountry! Our Coastal Cottage has luxury finishes, a gourmet kitchen, spacious bedrooms, and the new pool installed Spring of 2022 is ideal for discerning travelers of all ages. We pride ourselves on making sure your vacation time is special. Isle of Palms offers a premier beach vacation experience with pleasant beaches and delightful restaurants. We are a 5-minute walk to the beach on a quiet residential street away from the crowds.

Home in Folly Beach

4.93 out of 5 average rating, 237 reviews

Folly Vacation 204 Getaway, Relax & Unwind

This unique Spanish-style 2 bedroom, 1 1/2 bath beach house is in a quiet residential area with an easy walk to all the restaurants, shops and the ocean. Respectfully renovated to maintain its historic integrity, you’ll appreciate the mix of old and new. Dog friendly with a one-time fee of $110 per dog up to 3 nights, and $150 per dog for 4 or more nights. Fee is added once your reservation is confirmed. Rental Registration Number STR22-00313

Home in Cannonborough - Elliottborough

4.9 out of 5 average rating, 219 reviews

4BR/4.5BA - Prime Location - 2 Blocks to King ST

Beautiful 4 Bedroom/4.5 Bath Home in the Heart of Downtown! - 4 Master Bedrooms w/ En-Suite Bathrooms, + pullout sofa bed available - 2 Blocks from the iconic King Street - Off-Street Parking Provided - Walk to Everything! YOURPAD Charleston - Save On Your Stay! With over 75 eccentric homes throughout the heart of downtown Charleston, we encourage you to search YOURPAD Charleston on the web to view special offers.

Guesthouse in Johns Island

4.96 out of 5 average rating, 235 reviews

River Rd Retreat with Salt Wtr Pool, min to Beach

Gorgeous guest retreat above detached garage with pool access. Seven miles from Historic Downtown Charleston. Minutes from restaurants and the beach. This cottage is the best place to celebrate a special occasion! Send simple decorations through Amazon and we will decorate for you! Beach chairs, umbrella, and towels provided for your day at the beach. Kayaks and bikes available.

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Popular amenities for Santee vacation rentals

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Stay near Santee's top sights

Clark's Restaurant11 locals recommend

Captains Quarters Seafood and Steak11 locals recommend

Lonestar BBQ & Mercantile10 locals recommend

Armando’s Mexican Restaurant10 locals recommend

Lake Marion Golf Course7 locals recommend

Food Lion7 locals recommend

Other great vacation rentals in Santee

Home in Saluda County

4.89 out of 5 average rating, 114 reviews

Louie’s Paradise

Home in Summerton

4.83 out of 5 average rating, 103 reviews

Perfect family vacation retreat at Lake Marion, SC

Home in Chapin

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Home in Manning

5 out of 5 average rating, 25 reviews

Lakeside Hideaway

Home in North Charleston

5 out of 5 average rating, 34 reviews

Charleston - Pool - Near Airport, Downtown & Beach

Barn in Early Branch

5 out of 5 average rating, 114 reviews

Unique escape! 7 acres of woodsy paradise

Home in Isle of Palms

4.93 out of 5 average rating, 58 reviews

Coastal Escape: island Oasis with Pool + rooftop

Home in Park Circle

5 out of 5 average rating, 7 reviews

The Grand Marquis | Spacious Park Circle Bungalow

Quick stats about vacation rentals in Santee

Total rentals
10 properties
Nightly prices starting at
$100 before taxes and fees
Total number of reviews
160 reviews
Family-friendly rentals
10 properties are a good fit for families
Rentals with a pool
10 properties have a pool
Wifi availability
10 properties include access to wifi

Destinations to explore