Lake house vacation rentals in Santee
Find and book unique lake houses on Airbnb
Top-rated lake house rentals in Santee
Guests agree: these lake houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santee lake house rentals
Waterfront lakehouse rentals
Home in Lexington
4.87 out of 5 average rating, 143 reviewsLake Murray Paradise~2 BR, 1 Bth, Kit/Living area.
Home in Elloree
5.0 out of 5 average rating, 41 reviewsLake Front Property (Lake Marion)
Home in Manning
4.91 out of 5 average rating, 22 reviewsCozy Church Branch Cabin
Home in Summerton
4.93 out of 5 average rating, 15 reviewsStanley's Lake House
Home in Summerton
4.98 out of 5 average rating, 55 reviewsUltimate Lake Marion Dream Home W/Pool & Swim Spa
Home in Santee
5.0 out of 5 average rating, 14 reviewsSantee Sanctuary ~ Lakefront
Home in Summerton
4.94 out of 5 average rating, 31 reviewsCozy 3 bed 2 bath on the waterfront
Home in Summerton
4.81 out of 5 average rating, 31 reviewsFamily friendly lakefront home with boat ramp
Pet-friendly lake house rentals
Home in Vance
4.74 out of 5 average rating, 68 reviewsLake Marion Getaway!
Home in Summerton
5.0 out of 5 average rating, 11 reviewsCarolina Cottagecore
Home in Elloree
4.92 out of 5 average rating, 26 reviewsLakehouse
Home in Manning
4.86 out of 5 average rating, 36 reviewsJewel on the Lake
Home in Bonneau
5.0 out of 5 average rating, 10 reviewsLake House Retreat - Pet Friendly - Private Dock
Home in Summerton
5.0 out of 5 average rating, 22 reviewsA Lake Slice of Heaven
Home in Summerton
4.8 out of 5 average rating, 15 reviewsSantee/Lizzie's Creek Lakefront
Home in Swansea
4.97 out of 5 average rating, 33 reviewsSecluded lake house - 3 B.Room, 3 Bath - 3 Kayaks
Private lake house rentals
Home in Elloree
5.0 out of 5 average rating, 26 reviewsLured Away to our lakefront home
Home in Moncks Corner
4.95 out of 5 average rating, 39 reviewsCozy Little Nook
Home in Eutawville
4.91 out of 5 average rating, 35 reviewsLakefront home w/ Heated Indoor Pool and Dock
Home in Moncks Corner
4.97 out of 5 average rating, 65 reviewsLake Living
Home in Camden
5.0 out of 5 average rating, 62 reviewsBest Wateree Sunsets, many amenities w/ king bed!
Home in Summerton
4.84 out of 5 average rating, 44 reviewsFlip Flop Inn (Short Walk To Boat Ramp & Kayaks!)
Home in Ridgeway
5.0 out of 5 average rating, 17 reviewsThe Little House
Home in Georgetown
4.92 out of 5 average rating, 93 reviewsMaggie Jo’s paradise on the river !
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- Family travel hub Tips and inspiration
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