Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Summerton

5 out of 5 average rating, 35 reviews

Large Lakefront Home w/360 view, beaches, & dock

This family-friendly spacious lakefront home is located on a peninsula and boasts water access on three sides of the property. Park your boat at your own personal dock using the boat ramp located directly across from the property. This property has room for 11 people, but there is also access to an air mattress. Enjoy the 3 huge porches, fire pit, paddle boat, hammocks and swings, fishing day or night, drop in your kayaks or paddle board straight off the property and head out to Lake Marion.

Guest favorite

Home in Ridgeway

4.97 out of 5 average rating, 130 reviews

3000 sq ft lake house with views from every window

Lake Wateree 4 bedroom + bunk room with private dock and sleeps 12 comfortably. Our home has been completely renovated and is ready to enjoy! It is located in Ridgeway, SC and 20 minutes from Camden and Lugoff. Colonel Creek Landing is 4 miles away and the perfect location to launch your boat. You can dock your boat in 12 feet of water at our dock. Perfect location for fishing, kayaking and swimming. Two living spaces with smart tv's. Now you can enjoy the fire pit and outdoor shower.

Guest favorite

Home in Chapin

4.98 out of 5 average rating, 100 reviews

Bungalow Rustic House on Lake Murray, SC

3 Bedroom Bungalo Type Guest Home almost in the Lake. You can almost hang your legs off the back deck into the clean water of Lake Murray or just watch people put their boats in just across the lake at the public landing on Wessinger Road. We are in the no wake zone. You can be at the floating dock where you can tie up your boat or your rental pontoon in about a minute. Plus you are minutes from Publix, the Zoo, the State Capital and great places to eat. 6 Kayaks and a Row Boat with Oars

Guest favorite

Home in James Island

4.99 out of 5 average rating, 119 reviews

Waterfront Home Near Downtown!

Roomy waterfront home near Downtown Charleston! This 2 bedroom 1 bath home is perfect for family vacations or trips with friends. This stylish house is less than 5 minutes from Downtown Charleston and 15 minutes from Beautiful Folly Beach. Bring your paddle board or kayak and launch right from the back yard. This property is located right on Lake Francis and right outside you will see egrets, herons, ibis, and tons of other amazing birdlife. You will love your new home away from home!

Guest favorite

Home in North Charleston

4.95 out of 5 average rating, 111 reviews

The Tranquil Token: With Hot Tub & Ping Pong Table

-Come relax at our home! We've moved to a bigger space for our growing family, so we're renting out this cozy spot to fellow travelers like you. As Airbnb enthusiasts, we're excited to make your Charleston trip special. -Enjoy our 4-bedroom home with 5 beds in a quiet, safe neighborhood—ideal for families. Just a short 15-minute drive to Downtown Charleston for easy access to the city's attractions. We hope you love it as much as we did! - The Sullivan Family ❤️ Permit Number: 20240152

Guest favorite

Home in Lexington

4.97 out of 5 average rating, 147 reviews

Lakefront home on Lake Murray with private dock

Lakefront home on Lake Murray in Lexington, SC on over 1/2 an acre, 166 feet of waterfront with deep water, private dock, and entertainment space- perfect for an unforgettable vacation or weekend. Entire home for rent-4BR, 3 Bath +2 half baths, 2 sofa sleepers, sleeps 12. Breathtaking kitchen & large living space, perfect for the entire family. 2 single person kayaks, outdoor grill, 65 inch and 55 inch TV, washer/dryer, and fast wifi. Master suite with a lavish bathroom and soaking tub.

Guest favorite

Home in Gilbert

4.96 out of 5 average rating, 157 reviews

10 Mile View on Lake Murray w/ Dock and Ramp

Enjoy our Waterfront getaway on Lake Murray. It includes a private boat ramp, private dock, and over 600 sq ft deck across the entire lake front of the home. The front yard is large and perfect for cornhole, frisbee, and other activities. This cove is known for excellent kayaking, fishing, boating, and watersports. We have included 2 Kayaks and we work directly with a pontoon rental company if you would like a boat delivered. The .4 acre lot has plenty of parking for all guests.

Guest favorite

Home in Irmo

4.87 out of 5 average rating, 105 reviews

Lakefront w pool, dock and pool table, sleeps12

Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Guest favorite

Home in Moncks Corner

4.8 out of 5 average rating, 140 reviews

Lake Moultrie, Lake front with private dock

Lake front living. Sandy beach and private dock. Children and pets welcome. Enjoy swimming and fishing at your private resort. Local attractions are Old Santee Canal Park, with boardwalk along the Tail Race Canal. Pinopolis Lock, take your boat through the locks and travel to Charleston via intercoastal waterway. Mepkin Abbey, a working monastery and Cypress Gardens with hiking trails and butterfly house are in the area. Or you can simply stay at the cabin to unwind and relax.

Guest favorite

Home in Ridgeway

4.92 out of 5 average rating, 143 reviews

Enjoy Beautiful Lakefront Views!

IMPORTANT MESSAGE! ! ! Please remember, the Lake Wateree Dam is under a very extensive renovation and hopefully will be completed very soon! However, you can still enjoy viewing the lake from the gazebo and/or local fishing is within 1 to 2 miles from our home (Molly Creek Landing and Dutchman’s Cove) The beautiful new beach is also only within a 2 to 3 minute drive from our property too! Come on and stay anyway! Keeping our fingers crossed the dam is repaired soon!

Guest favorite

Home in Summerton

4.83 out of 5 average rating, 103 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Guest favorite

Home in Prosperity

4.99 out of 5 average rating, 152 reviews

Anchors Aweigh

You'll enjoy this small cabin located less than 2 miles from Dreher Island State Recreation Area. The views from the living area and kitchen are breath-taking. You can sit on the dock & watch the sun set or take your boat out just a few hundred yards to watch the sun rise. This location is great for swimming & a dock is available so you can bring your boat. There is also great fishing from the dock and on a boat. This will provide an unforgettable vacation!